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Kardie Tobb, DO, MS, FASPC, FACC, a boardcertified preventive cardiologist and the medical director for the Cone Health HeartCare Women's Heart Health and Cardio-Obstetrics Clinic, explains some of the most common reasons why GLP-1s may not deliver the results you're hoping for, including: You need a higher dose and have not yet reached a therapeutic dose as determined by your doctor High intake of liquid calories , including alcohol and ultra-processed foods Not getting enough protein , which can leave you persistently hungry and makes it harder to feel full Advanced diabetes or insulin resistance Taking other medications such as sulfonylureas, which lower blood sugar but can lead to weight gain Not adhering to your dosing schedule , such as inconsistent weekly injections or missed doses Differences in gut hormones or genetics And just because your GLP-1 isn't working immediately doesn't mean it won't work for you
Ji, K., Xiao, Y
The three most common active ingredients used in GLP-1s are semaglutide, liraglutide, and tirzepatide
reported that GLP-1 exhibited an osteogenic effect in diabetic rats, leading to enhanced bone strength and increased mRNA expression of bone-forming markers ( In vitro studies indicate that GLP-1 has osteogenic effects on various cellular sources, such as osteoblasts and bone precursor cells, consistent with our findings ( GLP-1RA has been shown to promote osteogenic differentiation and proliferation in vitro , this is consistent with our findings (Patel and Patel, 2017)
When performed by a skilled practitioner, injectables achieve subtle, natural-looking results that leave patients looking and feeling like the best version of themselves
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