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Retatrutide has shown a dose-dependent profile, with higher doses associated with a higher incidence of gastrointestinal events

2023;29(9):e13466

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Body weight and BMI play a role in determining eligibility for weight management trials, with most retatrutide studies enrolling adults with a BMI of 30 kg/m or above, or 27 kg/m or above in the presence of weight-related comorbidities such as hypertension or dyslipidaemia