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Certain genetic mutations, particularly those affecting the X chromosome, can be an underlying cause of premature ovarian insufficiency (also known as primary ovarian insufficiency), a condition in which menstrual cycles become irregular or cease and FSH levels are persistently high before the age of 40 years

10.1038/sj.cdd.4401706 25 KawamotoK.YagiM.StverT.KanzakiS.RaphaelY

Thats where methylcobalamin (Methyl B12) comes in

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Sperandio S, Poksay K, de Belle I, Lafuente MJ, Liu B, Nasir J, et al

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