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FDA enforcement discretion regarding certain compounded GLP-1 preparations ended on staged dates in February and March 2025 for tirzepatide and April and May 2025 for semaglutide

Taking your shot on the same day preserves that pharmacological stability and avoids the concentration dips that can worsen side effects or blunt efficacy ([Ozempic US Prescribing Information]( Practically speaking, consistency also builds habit

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Escalating to the maximum tolerated dose may improve appetite suppression and glycemic control

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The FDA approved the use of semaglutide to decrease the risk of kidney failure and disease progression, as well as death from cardiovascular disease in adults with type 2 diabetes and chronic kidney disease in January 2025 based on outcomes of the FLOW trial [130]