retatrutide triple agonist for weight loss: Study shows 30% body weight loss Retatrutide vs Mounjaro: triple agonist

May Reduce GI Side Effects vs

No significant changes in other weight-related biochemical markers were observed

Additionally, the proportional clavicular length change was 2.0 1.2% in lengthened cases and 5.0 5.3% in shortened cases

Altogether, the dataset examined more than 2 million veterans who were treated for diabetes from Oct 1, 2017, to Dec 31, 2023

Safety concerns : Important risks associated with GLP-1 receptor agonists include pancreatitis, gallbladder disease, dehydration leading to acute kidney injury, hypoglycaemia (when used with insulin or sulfonylureas), and potential worsening of diabetic retinopathy with rapid glycaemic improvement

Furthermore, GLP-1Rs on IELs have been found to regulate the metabolic effects of GLP-1 in animal models by entrapping it, thereby reducing its systemic availability and lowering its plasma concentrations (62)