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Obesity, insulin resistance and type 2 diabetes associated to PCOS will enhance the risk of endometrial cancer in PCOS patients [21, 22]

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Receptor Mechanism and Signaling GHRHR is a member of the class B family of G-protein coupled receptors (GPCRs), characterized by a large extracellular N-terminal domain that binds peptide ligands

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Resmetirom (a thyroid hormone receptor- agonist) was the first agent approved for MASH in March 2024 and remains a non-GLP-1 alternative for patients who cannot tolerate GLP-1 therapy or do not have obesity