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Additionally, studies in mice have demonstrated that -KG activates nuclear factor erythroid 2-related factor 2 (Nrf2) by activating the ERK signaling pathway in the endothelium of the thoracic aorta to counteract oxidative stress and mitochondrial impairment, thereby providing protective effects against endothelial damage induced by hyperlipidemia

10.1016/s0278-6915(98)00008-8 [DOI] [PubMed] [Google Scholar] Jain, R

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Bjorklund lost 150 pounds while taking the two drugs and sued the manufacturer for failing to warn about serious adverse gastrointestinal events