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Consequently, there is currently no effective clinical treatment for GBM, resulting in a 5-year survival rate of less than 5% [2]

These areas can experience extreme temperatures, which could compromise the medications effectiveness

Many patients remain on the 2.5 mg or 5 mg starting doses, which are primarily for tolerability rather than therapeutic effect, and do not reach the 10-15 mg weekly doses where maximal efficacy typically occurs

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As the chart shows, GLP-1s can only be prescribed for chronic weight management associated solely with obesity or a combination of obesity and glycemic control in people with type 2 diabetes

The decision to continue, taper, or stop should be individualized, not driven by arbitrary timelines