A majority of cats that require B12 supplementation, especially for GI disease, will require therapy for life
this is not an overnight transformation, but the cumulative effect over several months is significant for many patients
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it
Indeed, it is lack of antagonism and not necessarily synergy that should be the final goal of combinations, since synergy is not required for successful combination treatments in patients 86,87
The impact on fetus during pregnancy or children during breastfeeding has not been studied to sufficient extent, hence there is a need for caution
Physicians should weigh the potential therapeutic benefits against the risk of adverse outcomes