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The floxed IGF-1R (Stock No: 012251), floxed IGF-1 (Stock No: 016831), Chx10-EGFP/Cre (Stock No: 005105), transgenic glial high-affinity glutamate transporter (GLAST-Cre ER ) (Stock No: 012586), and albumin-Cre (Stock No: 003574) were purchased from the Jackson Laboratory (Bar Harbor, ME)