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Med Pediatr Oncol Suppl 2:18-22, 1992

Again the biomarker cooperated IGF-1 rose by roughly 51 ng/mL versus placebo but the functional recovery it was meant to drive largely did not materialize, and the trial ran into a safety signal serious enough to stop it

[PubMed: 16890642] 159

PLoS ONE 8 : e56293

It reduces eumelanin production, which is responsible for skin darkening