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Both mutants showed markedly reduced HGF-dependent c-MET activation (Fig

Three ABC transporters are most implicated in this phenotype, ABCB1 or P-gp (P-glycoprotein), ABCG2 or BCRP (Breast Cancer Resistant Protein) and ABCC1 or MRP1 (Multidrug Resistance Protein 1)

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Also targeting non-NMDA-R with positive allosteric modulation (PAM) of MGlu2/3 (polaglumetad, AZD8529) and of mGlu 5 receptors (VU040955) has been implemented

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