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Taken together, the available evidence positions BCAA supplementation as a disease-modifying nutritional intervention in advanced cirrhosis, with benefits operating through the three converging mechanisms outlined in Section 3.3.2: Fischer ratio correction, skeletal muscle ammonia clearance support, and mTORC1-mediated promotion of hepatocyte proliferation and protein synthesis

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[DOI] [PMC free article] [PubMed] 41.National Institute for Health and Care Excellence