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These medications are synthetic analogs or mimetics of human GLP-1 that resist degradation by the enzyme dipeptidyl peptidase-4 (DPP-4), allowing for prolonged therapeutic action

For oral semaglutide (Rybelsus), specific administration timing is critical: take once daily on an empty stomach with no more than 4 ounces of plain water, then wait at least 30 minutes before eating, drinking, or taking other oral medications

Visceral fat reduction , which lowers risk for heart disease and diabetes

What to track beyond timing While timing is the focus of this guide, tracking additional data points helps optimize your entire GLP-1 experience

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