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However, body composition changes from successful fat loss can affect insulin sensitivity independently

Some centres extend this to six months or beyond, but only where clinically indicated for example, in patients with ongoing reflux symptoms or confirmed gastro-oesophageal reflux disease (GORD)

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Interestingly, we observed that the cecal microbiome of previously-obese animals returned to the lean state through NNMTi treatment and LD switch was distinct from the cecal microbiome of continuously lean control animals

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