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If you are in doubt, always seek emergency care

In these cases, switching to a different glucose-lowering agent or stopping metformin altogether may improve tolerability

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The SURMOUNT-5 trial directly compared the two medications and found tirzepatide produced approximately 20 percent weight loss compared to 14 percent for semaglutide

Newer ones such as semaglutide and tirzepatide, broadly known as GLP-1s, have exploded in popularity for weight loss and have shown promise for treating other conditions, such as addictions and neurodegenerative and liver diseases

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