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Notably, rituximab ameliorates dyslipidemia in refractory SLE cases and attenuates myocardial infarction risk through pleiotropic immunometabolic mechanisms (157)

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Additionally, dietary protein-derived metabolites, including tryptophan-indole, as well as LPS from Gram-negative bacteria, directly promote the production of GLP-1 (66, 67)

Investigating two different cohorts (combined n = 3163), it was validated that individuals with high 2PY or 4PY levels have an increased risk of major adverse cardiovascular events