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Reduced body fat, particularly in stubborn areas

If you consumed alcohol regularly on semaglutide and did not lose weight, this could be a contributing factor regardless of which medication you take

Cochrane Database of Systematic Reviews , 2019(10)

This triple mechanism of action distinguishes retatrutide from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 receptor agonist)

Genetics and starting dose both influence whether you see week-1 results

Visible weight loss typically becomes noticeable between weeks 4 and 8, then gradually increases over the following months as the dose increases