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It acts as a non-selective melanocortin receptor agonist with the following binding profile (approximate Ki values): MC1R : ~0.67 nM (highest affinity, melanogenesis) MC4R : ~6.6 nM (appetite suppression, sexual function) MC3R : ~34 nM (energy balance) MC5R : ~46 nM (exocrine gland function) This broad receptor profile produces multiple physiological effects

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Elevated GH and IGF-1 drive the effects people seek, and the same elevation drives fluid retention, glucose changes, and the theoretical long-term concerns discussed below

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In general, however, geriatric adults are especially at risk for hypoglycemic episodes