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Moreover, as previously discussed, in a cecal ligation and puncture (CLP)-induced polymicrobial sepsis model, the conditional depletion of GPX4 triggers excessive lipid peroxidation and aggravates systemic inflammatory response that reportedly rely on GSDMD-dependent pyroptosis rather than ferroptosis [12]

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Key Precursors and Enzymes Precursor molecules and key enzymes The synthesis of GSH depends on three precursor molecules: glutamate, cysteine and glycine, and this process is catalyzed by key enzymes

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