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For a detailed discussion of the history of neurostimulators policy, we refer readers to the CY 2015, CY 2020, CY 2021, CY 2023, CY 2024, and CY 2025 OPPS/ASC final rules with comment period (79 FR 66807 through 66808

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Structurally, AOD 9604 retains a disulfide-linked cyclic conformation formed by cysteine residues, preserving key features of the native GH region responsible for lipid metabolism signaling

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