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I think the elephant in the room here is that GLP-1s reduce the risk of obesityand its possible that obesity is kind of the mother of all ills, Al-Aly says

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Nausea and gastrointestinal discomfortmore common GLP-1 side effectscan secondarily disrupt sleep by causing physical discomfort at bedtime

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The most common adverse effectsnausea, vomiting, abdominal pain, and diarrheaare often triggered or worsened by large portions and high-fat meals typical of restaurant dining

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