412 Notably, GLP-1RAs, including exendin-4, have been shown to attenuate microglial activation, resulting in a reduction in the expression of proinflammatory cytokines such as TNF- and IL-1
GLP-1R regulates brain glucose metabolism The most prominent physiological effect of GLP-1 and GLP-1R is the regulation of insulin secretion in the pancreas to maintain postprandial glucose homeostasis, whereas outside the pancreas, GLP-1 and GLP-1R also regulate feeding and metabolism through the nervous system
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And it is definitely not a reason to abandon a protocol that may be working
Eli Lilly & Company and the National Center for Advancing Translational Sciences Available from: Weiland G (1978) The enzyme-linked immunosorbent assay (ELISA)--a new serodiagnostic method for the detection of parasitic infections (authors transl)
