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Researchers also monitor tolerance or desensitization phenomena over time, as sustained agonism may reshape receptor trafficking

However, a slight numerical increase in suicidal ideation was observed among liraglutide recipients, with nine cases (0.3%) in the liraglutide group compared to two cases (0.1%) in the placebo group [71]

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Agent- and Dose-Specific Intestinal Obstruction Safety of GLP-1 Receptor Agonists

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