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To obtain a complete view of glutathione metabolism in each strain, using the same experimental panel, we examined the enzymatic activity of proteins involved in synthesis, reduction, conjugation of GSH along with the glutathione peroxidase activity that indicates the channelling of GSH towards the elimination of peroxide species produced by the oxidative stress

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The pH of aqueous solutions of selenium was set at 5.0

In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising an alkyl-glycoside and/or a saccharide alkyl ester