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Studies have documented up to 50% reduction in respiratory function of skeletal muscle mitochondrial complexes IIV in metabolic syndrome conditions including PCOS, with mitochondrial swelling and cristae structural disruption forming the structural basis for muscle functional impairment (60)

Avoid the inner thigh, where blood vessels and nerves are closer to the surface

However, supplementation needs differthe NHS recommends vitamin D (10 micrograms daily) for everyone during autumn and winter, whilst B12 supplementation is primarily needed by vegans, those with malabsorption conditions, or pernicious anaemia

Stem Cell Reviews and Reports , 16 (1), 118125

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