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Although the antioxidant capacity of flavonoids may be compromised after reacting with ROS, recent studies have shown that the oxidized derivatives of certain flavonoids can significantly enhance their original antioxidant properties by activating the NRF2/KEAP1 pathway and upregulating the cell's endogenous antioxidant capacity [423]
This combinatorial strategy may not only enhance anti-tumor immune responses through the release of DAMPs and tumor-associated antigens from ferroptotic cells but also simultaneously induce selective and potent cell death in GBM, potentially overcoming therapeutic resistance mechanisms
5 Conclusion and outlook Cancer cells show overexpressed GSH that may maintain redox homeostasis to protect cells from oxidative damage, as well as reduce the chemotherapeutic agent-induced toxification
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Free Radic Biol Med 122:110115 Lisenbee CS, Lingard MJ, Trelease RN (2005) Arabidopsis peroxisomes possess functionally redundant membrane and matrix isoforms of monodehydroascorbate reductase
