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This condition, formerly known as PCOS (polycystic ovary syndrome), is often tied to insulin resistance and higher levels of androgens (so-called male sex hormones like testosterone that female bodies typically produce at low levels)
The medication works by enhancing insulin secretion in a glucose-dependent manner, meaning it stimulates insulin release only when blood sugar is elevated
You should contact your GP or healthcare provider if you experience: Persistent green stools lasting more than a week without obvious dietary explanation Black, tarry stools (melaena), which may indicate upper gastrointestinal bleeding Bright red blood in stools (haematochezia) or on toilet paper Pale, clay-coloured, or white stools , which could suggest bile duct obstruction or liver problems Diarrhoea lasting more than 48 hours , particularly if accompanied by dehydration symptoms Severe abdominal pain , especially if localised to the upper abdomen and radiating to the back, which could indicate pancreatitis (a rare but serious side effect of GLP-1 receptor agonists) Right upper quadrant pain , particularly after fatty meals, which may suggest gallbladder problems Yellowing of the skin or eyes (jaundice) with dark urine, which could indicate liver or gallbladder issues Signs of dehydration: excessive thirst, dark urine, dizziness, reduced urination, or dry mouth Persistent vomiting preventing adequate fluid or medication intake Unexplained weight loss beyond expected therapeutic effects Fever accompanying stool changes , suggesting possible infection For urgent but non-emergency concerns, contact NHS 111
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It also enhances the activity of detoxification enzymes, such as glutathione S-transferases (GSTs), which conjugate toxins to Glutathione, facilitating their elimination (Lu, 2013)
