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The SURMOUNT-OSA master protocol comprised two, 52-week, randomized, double-blind, placebo-controlled phase 3 studies (study 1 and study 2) and demonstrated a significant reduction of a number of cardiometabolic risk measures in participants with OSA and obesity following treatment with tirzepatide

However, the mechanism of GLP-1R in treating obesity is still uncertain, and more clinical evidence is needed for its long-term safety and efficacy

Studies have also shown that the gut microbiota could induce the transcription of Tph1 and Tph2 and subsequent 5-HT production (Yano et al., 2015)

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It comes as Mounjaro and Zepbound