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Seek urgent medical attention (contact 999, NHS 111, or attend A&E) if you experience: Black, tarry stools (melaena) may indicate upper gastrointestinal bleeding Bright red blood in or on stools, particularly if accompanied by dizziness, weakness, or rapid heartbeat Pale or clay-coloured stools with yellowing of skin or eyes (jaundice) potential biliary obstruction or liver dysfunction Severe abdominal pain with stool changes, especially if persistent or worsening Stop your GLP-1 medication and seek urgent medical assessment if you develop symptoms suggestive of pancreatitis (severe, persistent abdominal pain which may radiate to your back, with or without vomiting)
doi: 10.1016/j.omtn.2019.11.015 262 YanSWangPWangJYangJLuHJinCet al
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Consult your healthcare provider if you take herbal supplements before taking spironolactone
This suggests that the body needs time to adjust to receptor activation, and giving it that time through gradual escalation reduces discomfort regardless of when during the day you inject
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