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Oxidative stress is the disturbance in the balance between the generation of free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), and antioxidant defenses, and can cause oxidative damage to diverse cellular components, such as membranes, proteins, and DNA

Guidelines suggest the additional use of DPP-4 inhibitors after metformin failure in patients that do not require antidiabetic therapy with proven cardiovascular benefit

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Neuronal activation mapping using cFos immunostaining in the area postrema (AP), nucleus tractus solitarius (NTS), and lateral parabrachial nucleus (LPBN) provided mechanistic insight

1998 Nov;139(5):552-61 (2 Tavares AB, Micmacher E, Biesek S, Assumpo R, Redorat R, Veloso U, Vaisman M, Farinatti PT, Conceio F