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It peaks 1 to 3 hours after injection, can persist at lower levels for 12 to 24 hours, and typically resolves within 48 hours
Cancer Cell 18 , 397397 (2010)
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On day 10 after inoculation, tumor-bearing mice were treated with vehicle (saline), APR-017(100 mg/kg per day, ip., for 10 days), IC261(0.6 mg/kg per day, ip., for 10 days), or APR-017 + IC261, and tumor growth was monitored via in vivo imaging (IVIS)
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