As permeant ion channel blockers of AMPARs and KARs, cytoplasmic polyamines (spermine, spermidine, putrescine) have been identified as critical modulators of neuronal signaling, influencing action potential firing rates as well as the efficacy of neurotransmission (Nichols and Lopatin, 1997)
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Safety Profile and Known Risks Water Retention and Joint Discomfort The most commonly reported adverse effects of GH-stimulating peptides are mild fluid retention and transient joint aching, consistent with the known side-effect profile of recombinant human GH (rhGH) therapy
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