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Il prezzo da pagare, sul piano farmacologico, il metabolismo via CYP3A4: un terreno con cui ogni medico ha familiarit da molte altre classi, ma che impone tre attenzioni puntuali (simvastatina, contraccettivi orali, insufficienza epatica severa) e una gestione consapevole di induttori e inibitori del citocromo