Initially characterized as the second incretin hormone [51], GLP-1 was later found to have pleiotropic action well outside the pancreas, with broad action in the brain and the periphery and which includes decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, modulation of rodent -cell proliferation, decrease of inflammation and apoptosis, improvement of cardiovascular function, and modulation of learning and reward behavior [52] (Fig
"It's exciting to see obesity approaches starting from the brain, which encourages people to follow the recommended diet plan." This means there is unlikely to ever be a 'magic pill' treatment, which can help patients lose weight, and keep the weight off in the long term, without them also following a strict diet-and-exercise regime
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Lenzi, A., Lombardo, F., Gandini, L., Culasso, F., & Dondero, F
His job required him to stay mobile, and recreational sports were an important part of his routine
It stimulates insulin secretion from pancreatic beta cells in a glucose-dependent manner, meaning it only triggers insulin when blood sugar is elevated