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Rodent studies have shown that treatment with liraglutide or once-weekly exenatide is associated with thyroid C-cell proliferation and the formation of thyroid C-cell tumors ( Therefore, the US Food and Drug Administration (FDA) prohibits these therapies for patients with an individual or family history of medullary thyroid carcinoma (MTC) or patients with multiple endocrine neoplasia syndrome type 2 (MEN2)