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Research Summary 5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue and linked to obesity and metabolic dysfunction

doi: 10.1111/sji.13106 13 OttavianiJIFongRKimballJEnsunsaJLBrittenALucarelliDet al

While the function of transmembrane protein SLC7A11 is primarily affected by its membrane localization, the mechanism regulating the intracellular transport and membrane location of SLC7A11 is rarely documented

This rapid degradation is crucial because single amino acids and tiny di-peptides are not recognized as threats by the immune system

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Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madiraju SR, Goulet D, Viallet J, Belec L et al (2007) Small molecule obatoclax (GX15070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis