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UKPDS outcomes model 2: a new version of a model to simulate lifetime health outcomes of patients with type 2 diabetes mellitus using data from the 30 year United Kingdom Prospective Diabetes Study: UKPDS 82

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Elevated levels of cytokines, such as TNF- and IL-6, disrupt the testicular microenvironment, affecting nutrient supply and metabolic balance essential for sperm production [67]

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Consistent with previous reports (20,28), our results demonstrate IGF-1 signaling postnatally is important for the acquisition of bone mass