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Novo Nordisk announced FDA acceptance of their New Drug Application (NDA) for a 25 mg oral version of Wegovy for two new indications: (1) chronic weight management in adults living with obesity or who are overweight with at least one comorbid condition, and (2) to reduce the risk of major adverse cardiac events (MACE) in adults with overweight or obesity and established CVD
Advancement from mild paresthesia to intensifying sharp or burning pain deserves careful monitoring
1 and Supplementary Sections 4 and 5) and 96 clinical studies (Tables 16, Fig
Stretch Out Your Injections
Oxidative stress and endothelial dysfunction in sepsis and acute inflammation
Additional considerations include diabetic retinopathy status (semaglutide may worsen retinopathy in some patients with pre-existing disease, particularly with rapid A1c improvement), history of pancreatitis (use GLP-1 agents with caution), and upcoming surgical procedures (discuss with your surgical/anesthesia team due to effects on gastric emptying)
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