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The downregulation of both MMP-2 and MMP-9 delays the epithelial-mesenchymal transition (EMT) because this inhibition reduces the capacity of osteosarcoma cells to degrade the ECM, migrate, and infiltrate tissues by 40% to 70% 64,65

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Environ Pollut 308:119606 Cobbett CS, May MJ, Howden R, Rolls B (1998) The glutathione deficient, cadmium-sensitive mutant, cad2-1, of Arabidopsis thaliana is deficient in -glutamylcysteine synthetase