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Some IBS cases are tied to gut-brain signaling and pain sensitivity

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Foods such as chips, pastries, full-fat takeaways, and heavily buttered dishes slow gastric emptying even further, compounding the drug's existing effect and increasing the risk of nausea, vomiting, and upper abdominal discomfort

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Structural comparison with Conformer 1 showed that there is a small but remarkable shift of the entire G i heterotrimer relative to the receptor with a ~15 rotation of the N-terminal -helix (N) and ~10 rotation of the C-terminal -helix (5) of G i in Conformer 2 (Fig

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