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EASL Clinical Practice Guidelines: Wilson disease

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Oxidation stress is the imbalance between oxidants and antioxidants in favour of the oxidants, potentially leading to damage

Based on in vitro studies, CYP3A4 and CYP2D6 enzymes are responsible for dehydrogenation and hydroxylation of aripiprazole, and N-dealkylation is catalyzed by CYP3A4

Conversely, patients who begin immunotherapy while receiving corticosteroids (for example, in the treatment of brain metastases) appear to have worse outcomes 10