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Spermidine/spermine N1-acetyltransferase 1 (SSAT) initiates polyamine catabolism, which decreases the cellular content of polyamines through transferring the acetyl group of acetyl-CoA to either spermidine or spermine, which can be oxidized by peroxisomal enzyme polyamine oxidase (PAOX)

GHK-CU, Epithalon, and MOTS-C are not FDA-approved for anti-aging, longevity, or metabolic optimization purposes

There was a study presented at a national meeting looking at the role of bariatric surgery in patients with obesity and the impact on cancer prevention, and it found a marked decrease in cancer diagnoses in patients with obesity who underwent bariatric surgery compared to those who didn't

Relevant as a historical reference and for short preclinical protocols that aim to replicate native GHRH pharmacology (29 amino acids, 10-minute half-life)

Maintenance doses may cost less than initial treatment phases