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Reduce if gastrointestinal symptoms remain severe after six or more weeks at a given dose level, if significant dehydration results from persistent vomiting or diarrhea, if heart rate increases beyond 15 beats per minute above baseline, or if the side effect burden is causing protocol abandonment

it was sold to QuidelOrtho in 1995 for $3.95 million

Patients with well-controlled reflux on proton pump inhibitors or H2 blockers have successfully completed weight loss programs using GLP-1 medications without significant complications

Schoellhammer CM, Blankschtein D, Langer R