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Ongoing research The semaglutide-allodynia connection is an active area of investigation

Animal models show microbiota changes prior to motor symptoms, and probiotic interventions have improved GI and non-motor symptoms in clinical trials

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The Bottom Line (Plain English) Weeks 12: appetite changes, little scale movement Weeks 36: weight loss often begins Months 36: meaningful, sustained loss for many Semaglutide: slower start, steady progress Tirzepatide: faster early loss for some, same long-term rules apply GLP-1 rewards patience not urgency