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Yet another potential anticancer mechanism of fingolimod is inhibition or degradation of SK1, which is upregulated in multiple cancers, including CNS (brain), gastrointestinal (colon, stomach, rectum, small intestine), genitourinary (ovary and uterus), pulmonary and breast (121)

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These cells were extracted from tumors coming from Th- MYCN transgenic mice over-expressing MYCN gene under the control of the tyrosine hydroxylase promoter