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Side-Effect Tolerability and Who Should Consider Each Option Both medications cause gastrointestinal side effectsprimarily nausea, vomiting, constipation, and appetite suppression

Topics include the landscape of GLP-1 drug-device combination products in the US market, regulatory framing of acceptable UI differences, current CUHF study guidance and design fundamentals, case examples for pen injectors and autoinjectors, alternative CUHF approaches, device platform-based approaches for CA and HF data sharing, engineering considerations for generic GLP-1 injectors and drug-device interfaces, and CMC considerations for device evaluation

Nature Communications, 10(1), 5284

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They arent right for everyone, and the side effects can be significant