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Previous studies on the efficacy of oral antihyperglycemic agent triple combination therapy have been, for the most part, conducted with add-on therapy with metformin and sulfonylurea [21]

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Messages travelling through the vagus nerve are necessary for instructing the gut to perform several essential functions: Stomach acid secretion and muscle propulsion Digestive enzyme release from the pancreas Intestinal secretion of brush border enzymes Intestinal motility and mucous production Source: Furthermore, the vagus nerve is also responsible for modulating the permeability of the intestinal barrier

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