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I was in a really dark place, says McKenzie, whose weight had climbed to 335 pounds on his 6-foot-1 frame, despite repeated efforts to diet and exercise

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Also, patients with pregnancy, breast feeding, patients suffering from endocrine diseases, autoimmune disorders, chronic debilitating diseases like malignancy, decompensated cardiac, pulmonary, renal, or hepatic diseases were ruled-out

The body interprets weight loss as a threat to survival and responds by slamming the brakes on metabolism through sophisticated energy-conserving mechanisms

However, weight loss results are generally modest, averaging 510 pounds over several months

A dedicated study in the Journal of Clinical Pharmacology confirmed this specifically for birth control pills