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Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis

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Release of Ca2+ from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells

This would also enable prescribers to lawfully prescribe these substances consistent with their prescribing authority under applicable state law and the broad discretion afforded to physicians under the practice of medicine

Cell Metab 16(4):487499 Stewart C, Estrada A, Kim P, Wang D, Wei Y, Gentile C et al (2017) Regulation of IRE1alpha by the small molecule inhibitor 4mu8c in hepatoma cells